tauroursodeoxycholic acid sodium
牛磺熊去氧胆酸(Tauroursodeoxycholic acid)
CAS: 14605-22-2
化学式: C26H45NO6S
| 中文名 | 牛磺熊去氧胆酸 |
| 英文名 | Tauroursodeoxycholic acid |
| 别名 | 牛磺脱氧胆酸 牛熊去氧胆酸 牛磺雄去氧胆酸 牛磺熊脱氧胆酸 牛磺熊去氧胆酸 牛磺酸熊脱氧胆酸 牛磺酸熊去脱氧胆酸 牛磺熊去氧胆酸标准品 牛磺熊去氧胆酸(牛磺熊脱氧胆酸) TAUROURSODEOXYCHOLIC ACID 牛磺熊去氧胆酸 牛磺熊去氧胆酸(牛磺脱氧胆酸,牛熊去氧胆酸钠,牛磺酸熊脱氧胆酸,牛磺熊脱氧胆酸钠盐,牛磺酸熊去脱氧胆酸) |
| 英文别名 | yl)amino)- TUDCA Soduim Salt Ursodeoxycholyltaurin ursodeoxycholyltaurine Tauroursodeoxycholic acid tauroursodeoxycholic acid sodium 9,10-secocholesta-5,7,10-trien-3-ol 3α,7β-dihydroxy-5β-cholan-24-oic acid n-(2-sulfoethyl)amide 3a,7b-Dihydroxy-5b-cholan-24-oic Acid N-(2-Sulfoethyl)amide 2-{[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid 2-{[(3alpha,5beta,7beta,8xi,9xi,14xi)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid |
| CAS | 14605-22-2 |
| EINECS | 1308068-626-2 |
| 化学式 | C26H45NO6S |
| 分子量 | 499.7 |
| InChI | InChI=1/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1 |
| InChIKey | BHTRKEVKTKCXOH-LBSADWJPSA-N |
| 密度 | 1.216±0.06 g/cm3(Predicted) |
| 熔点 | 173-175°C |
| 沸点 | 496.4°C at 760mmHg |
| 比旋光度 | (C=1, EtOH)+46 |
| 溶解度 | 溶于DMSO (高达30毫克/毫升) 或乙醇 (高达20毫克/毫升，加热) |
| 折射率 | 46 ° (C=1, EtOH) |
| 酸度系数 | 1.42±0.50(Predicted) |
| 存储条件 | +15C to +30C |
| 稳定性 | 从提供的购买之日起稳定1年。DMSO或乙醇中的溶液可以在-20 °C下储存长达1个月。 |
| 外观 | 固体 |
| 颜色 | White |
| MDL号 | MFCD00069496 |
| 体外研究 | Tauroursodeoxycholate (TUDCA) suppresses both viability and migration of vascular smooth muscle cells (VSMCs) through inhibition of ERK phosphorylation, by induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) via PKCα. Tauroursodeoxycholate inhibits both the proliferation and migration of VSMCs via inhibition of ERK, through Ca 2+ -dependent PKCα translocation. Tauroursodeoxycholate prevents platelet-derived growth factor (PDGF) and vascular injury-induced MMP-9 expression. The knock-down of MKP-1 using specific si-RNA restores the reduced VSMC viability by Tauroursodeoxycholate (200 μM), which suggests that anti-proliferative effect of Tauroursodeoxycholate depended on the MKP-1 expression. |
| 体内研究 | The effects of Tauroursodeoxycholate (TUDCA) on proliferation and apoptosis of VSMCs in vivo are examined using immunohistochemistry for proliferating cell nuclear antigen (PCNA) and the transferase dUTP nick-end labelling (TUNEL) assay. Tauroursodeoxycholate (10, 50, and 100 mg/kg) increases the caspase 3 activity of injured tissues in a dose-dependent manner, indicating that Tauroursodeoxycholate induces apoptosis of VSMCs in the neointima. Using the injured tissues, further examination and comparison of the phosphorylation level of ERK and MMP-9 expression is performed at 1 week after injury, compared with normal controls. Balloon injury increased both the phosphorylation of ERK and expression of MMP-9 in the tissues. Tauroursodeoxycholate (10, 50, and 100 mg/kg) inhibits phosphorylation of ERK and MMP-9 expression in a dose-dependent manner. Tauroursodeoxycholate (TUDCA) is a hydrophilic bile acid. Tauroursodeoxycholate as a cytoprotective agent improves liver function and can prevent hepatocellular carcinoma by reducing ER stress and apoptosis. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3, caspase-12, C/EBP homologous protein, c-Jun N-terminal kinase (JNK), activating transcription factor 4 (ATF4), X-box binding protein (XBP), and eukaryotic initiation factor 2α (eIF2α) in Ang II induced ApoE -/- mice (p<0.05). Tauroursodeoxycholate reduces Angiotensin (Ang) II induced abdominal aortic aneurysm (AAA) formation in ApoE -/- mice. Tauroursodeoxycholate is used at a dose of 0.5 g/kg/day in treating Ang II induced ApoE -/- mice (ER stress inhibitor group). Systolic blood pressure (141.3±5.6 mmHg vs 145.9±8.9 mmHg; p>0.05) and total cholesterol levels (663.6±88.7 mg/dL vs 655.7±65.4 mg/dL; p>0 .05) do not differ between the AAA model group and Tauroursodeoxycholate group. In addition, maximum aortic diameter is significantly smaller in those in Tauroursodeoxycholate group compared with those in the AAA model group (0.95±0.03 mm vs 1.79±0.04 mm; p<0.05). AAA lesion areas are also smaller in those in Tauroursodeoxycholate group than in those in the AAA model group (0.37±0.03 mm 2 vs 1.51±0.06 mm 2 ; p<0.05). |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 2 |
| RTECS | KI7372500 |
| 海关编号 | 29242990 |
| 参考资料 展开查看 | 1. 杨金伟,赵灿,刘秀,吴勇军,喻嵘.左归降糖舒心方含药血浆对ox-LDL诱导小鼠巨噬细胞泡沫化和凋亡的影响[J].南京中医药大学学报,2020,36(03):370-375. 2. 曹妍,李婷,常安琪,蒋珍珍,于娟,屠鹏飞,宋月林.蛇胆中胆汁酸类化学成分分析[J].中国中药杂志,2021,46(01):130-138. 3. Wang, Tianyang, et al. "Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS." Analytical and bioanalytical chemistry 412.5 (2020): 1215-1234. 4. Song Lin, Tian-yang Wang, Hua-rong Xu, Xin-nong Zhang, Qi Wang, Ran Liu, Qing Li, Kai-shun Bi,A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induce 5. [IF=3.361] Qingqing Song et al."Polarity-extended quantitative analysis of bear bile and its analogues using serially coupled reversed phase-hydrophilic interaction liquid chromatography-tailored multiple reaction monitoring."Rsc Adv. 2017 Nov;7(83):52822-52831 6. [IF=8.322] Hou Yonghui et al."Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response."J Neuroinflamm. 2021 Dec;18(1):1-13 7. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 8. [IF=5.878] Min Wen et al."Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis."Phytother Res. 2021 Jul;35(7):3799-3811 9. [IF=5.396] Shiming Huang et al."A sulfated polysaccharide from Gracilaria Lemaneiformis regulates cholesterol and bile acid metabolism in high-fat diet mice."Food Funct. 2019 Jun;10(6):3224-3236 10. [IF=5.396] Cong Liang et al."Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57BL/6J mice."Food Funct. 2021 May;12(10):4315-4324 11. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 12. [IF=0.252] Yi Dong et al."Mechanism of tauroursodeoxycholic acid-mediated neuronal protection after acute spinal cord injury through AKT signaling pathway in rats."Int J Clin Exp Patho. 2020; 13(9): 2218–2227 13. [IF=5.396] Juan Wu et al."Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes."Food Funct. 2022 Feb;: 14. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 |
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现货供应
产品名: 牛磺熊去氧胆酸 标准品 去供应商网站查看 询盘CAS: 14605-22-2
产地: 北京
包装: 瓶
规格: ST8580-20mg,20mg,IT0790-20mg,20mg,IT0790-100mg,100mg,IT0790-1ml,10mM*1ml in Water
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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